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Primary mitochondrial disease and secondary mitochondrial dysfunction: Importance of distinction for diagnosis and treatment

Slower escalation with better tolerance produces better long-term adherence and results than aggressive dosing that causes misery

In one of our previous studies [80], we found that the levels of NNMT expression in extensor digitorum longus muscles (a typical type of fast-twitch muscle relying on anaerobic metabolism to produce power) are higher than those in the soleus muscle (a typical type of slow-twitch muscle relying on aerobic metabolism to produce power) and that anaerobic exercise is more effective in increasing NNMT expression in skeletal muscles compared to aerobic exercise