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It consists mainly of mannitol, trehalose, and non-starch polysaccharides like beta-glucans

Specifically, cryostress increases plasma membrane permeability, which in turn promotes excessive generation of reactive oxygen species (ROS) and exacerbates lipid peroxidation (LPO)

This novel link to epigenetic plasticity during epithelial-to-mesenchymal transition adds to previous studies showing a role for iron in metastatic ability likely through downregulation of N-myc downstream-regulated gene 1 (NDRG1) [16], a metastatic suppressor that is usually decreased in several types of cancer

Daily injection is the standard protocol