In addition, xCT expression can be regulated by the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/PKB/mTOR) 29,30,31 and mitogen-activated protein kinase (MAPK) pathways in synergy with activating transcription factor 4 (ATF4), which is activated by endoplasmic reticulum stress
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
In an APP/PS1 model of AD, D-Ala2-GIP reduced activation of chronic inflammatory response in the brain, oxidative stress, synapse loss, amyloid plaque burden, and DNA damage [106]
This review evaluated several plant polysaccharides that have been proven to exert potential antitumor effects through ferroptosis, showing promise as novel candidate drugs (Table 1)