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Reactive oxygen species (ROS) can cause Ape-1, a multifunctional protein that regulates apoptosis, to be produced (Ramana et al., 1998)

Whole genome sequencing identified 13 heterozygous mutations in SMARCC2 which are shown to be de novo and had given rise to neurodevelopmental delay and growth retardation in 15 individuals ( Whole-exome sequencing on 13,933 patients with major BD and 14,422 controls identified ultra-rare protein-truncated variants (PTVs) in both BD major subtypes (bipolar I disorder and bipolar II disorder)

Turkish Journal of Gastroenterology, 34 (2), 89100

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