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Saxena D, Maitra R, Bormon R, et al

DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss

The hydrophobic core accommodates hydrophobic drugs via noncovalent interactions, whereas the hydrophilic shell can be chemically modified with responsive groups for controlled or targeted release (225)

Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis