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While using heat-damaged medication is usually not toxic, it will likely result in a stalled weight loss journey because the drug is no longer doing its job

Its active ingredient is tirzepatide, a GIP receptor agonist that activates both the GLP-1 and GIP receptors to improve blood sugar regulation

Consider two people who both lose 15 kilograms on a GLP-1 drug: Lost 15 kg but poorly 10 kg fat lost 5 kg muscle lost Metabolic rate has fallen Blood sugar control worsened Higher fall risk than before Weight regain likely as fat Lost 15 kg and well 14 kg fat lost 1 kg muscle lost (or neutral) Metabolic rate preserved Blood sugar control improved Strength maintained or increased Better long-term weight maintenance Both people lost the same amount of weight by the scale

In fact, previous studies have shown that serum LPS has various effects in the CNS, including the overactivation of microglia and an increased production of proinflammatory cytokines (116)