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Spatial transcriptomics showed increased gene responses linked to beta cell stress ( Hspa5 , Eif2ak3 , Xbp1 , Ddit3 ), dedifferentiation ( Cd81 ), disallowed genes ( Oat , Igfbp4 ), antigen presentation ( H2-K1 , H2-Q6 , H2-Ab1 , H2-Eb1 ) and inflammation ( Cxcl10 , Cxcl9 , Ccl5 ) during disease progression

StatPearls Publishing, Treasure Island Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P (2015) Autoimmune thyroid disorders

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The use of topical moisturizers, salicylic acid, lactic acid, urea, vitamin D, or tretinoin may be of benefit, but the plugs usually reappear when treatment is discontinued