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Key Takeaways Store unused GLP-1 medications in the refrigerator at 36F46F (2C8C) Never freeze your medication frozen pens must be discarded In-use pens can stay at room temperature for a limited time ( 2156 days depending on the medication ) Heat above 86F and direct sunlight can damage the medication Compounded vials should remain refrigerated at all times Florida heat and travel increase the risk of improper storage If the medication looks cloudy or was exposed to extreme temperatures, do not use it Why Storage Matters for GLP-1 Medications Medications such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are made from proteins