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Hyperacetylation was associated with an elevation in expression of pro-apoptotic genes such as Bax and P21

Hepatitis/Elevated liver enzymes/Jaundice Diabetic retinopathy problems: Changes in vision in those with type II diabetes, particularly vision problems may worsen in those with a history of diabetic retinopathy Severe gastrointestinal disease: May cause gastrointestinal disease

Research Applications PT-141 has been utilized as a molecular probe in controlled experimental systems examining: Central melanocortin receptor pharmacology (MC3R, MC4R) Hypothalamic and limbic circuit characterization Mesolimbic dopaminergic pathway modulation Autonomic nervous system signaling models Neuroendocrine regulatory pathway research Melanogenesis and MC1R-mediated pigmentation signaling Energy homeostasis and metabolic feedback models