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In the FF, melatonin eliminates free radicals and stimulates antioxidant enzymes in addition to promote sex steroid hormone production by granulosa cells which support follicle development leading to ovulation (3)
For the mediation analysis on the histology endpoints evaluating change in body weight as mediator, data were based on complete-case on-treatment measurements to evaluate the mechanistic action of semaglutide in MASH (hence, data outside the on-treatment observation period were excluded)
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