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doi: 10.1016/j.jpeds.2015.09.076

The rising level of the inflammatory transcription factor, nuclear factor-kappa B, and activation of TNF- is caused by ROS

Being overweight is one of the common causes of back pain, especially in the lower back When considering that the majority of Americans are overweight, it is easy to see why back pain is becoming an epidemic in the United States

LRRK2 also regulates mitophagy through interaction with Miro, which anchors mitochondria to microtubules in mitochondria axonal transport (Wang et al., 2011)