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In one study involving 6,455 treatment courses of acetylcysteine, it doesnt seem that there was any serious harm from anaphylactoid reactions (e.g., death)

Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al

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Some advanced users run longer cycles or higher doses: 4-6 week cycle: 20-50 mcg daily, 4-6 weeks off (less common, higher risk) Bilateral IM split: 40-80 mcg/day split between muscle groups post-workout Training-day only: 50 mcg on training days (4-5x/week) for 4 weeks The standard 10-day on / 4-week off protocol is the most commonly documented starting point in community sources