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By assessing overall health and hormone patterns, providers can help patients understand whether these changes are part of perimenopause or related to another condition that requires attention

Lofton adds that many prescribers may not feel comfortable prescribing these medications (They have not been properly trained or dont understand the complexity of overweight and obesity as chronic medical conditions, she says), making it difficult for patients to get the drug from their primary care physicians

As a result, there has been a growing demand for oral GLP-1 RAs that offer greater ease of administration compared to oral semaglutide

Nat Rev Dis Primers 11 , 49 (2025)