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Without glutathione, then, this feedback inhibition is removed, and there is an upregulation of this enzyme, resulting in increased amounts of gamma-glutamyl cysteine, which itself is a precursor to the organic acid 5-oxoproline
These findings demonstrate that this strategy can not only generate mutation-specific KRAS degraders using selective ligands, but also leverage broad-spectrum KRAS ligands as platforms for developing pan-KRAS degraders