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The symptoms of B12 deficiency will start showing up after that period. 2

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demonstrated that intentional weight loss significantly improved the response of obese PsO patients to low-dose cyclosporine (67) This finding underscores the broader concept that improving metabolic health can enhance responsiveness to immunosuppressive treatments and provides a rationale for combining metabolic interventions with systemic therapies, including GLP-1RAs

While its true that there are adverse effects that accrue from being obese, its also true that being perfectly healthy isnt really the point of life