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Initially identified as a stress-responsive protein upregulated during the unfolded protein response (UPR) and ER stress (Mungrue et al., 2009), CHAC1 plays dual roles in cellular regulation

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The main drivers for weight regain after significant WL include the persistence of a lower resting metabolic rate and the increased appetite, possibly mediated through long lasting increased orexigenic and decreased anorexigenic signals [2, 6]

Visceral versus subcutaneous fat While the trial did not break down visceral and subcutaneous fat reduction separately using imaging for all participants, the liver fat data serves as a strong proxy