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albicans were co-infected, a thicker, denser biofilm with stronger tolerance to harmful stresses was formed on root canal dentin and glass slides, which can increase bone resorption of osteoclasts, inhibit the bone formation of osteoblasts, upregulate inflammatory cytokines such as IL-6 and TNF-, and ultimately increase the severity of dental pulp diseases

The enzyme was dissolved in phosphate-buffered saline at pH 7.4, sterilized through a 0.22-m membrane, and administered under ultrasound guidance

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It contains balanced amount of all the important water soluble vitamins which act as coenzymes of vital enzymes associated with crucial physiological processes, energy metabolism, cell growth and replenishment especially in brain and nerve cells