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The phospholipid bilayer of liposomes resists the catabolic effects of gastric acid and digestive enzymes, allowing glutathione to reach absorption sites such as the small intestine intact

Schwandt, Hans-Joachim (2019)

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What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are glucose sensors , activated during caloric restriction and fasting The decline in NAD+ leads to pseudohypoxia in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field