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Effectiveness of enamel matrix derivative in conjunction with particulate autologous bone in the treatment of noncontained intrabony defects: A 2-year prospective case series

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Metabolic profiling of dried blood spots from patients with HS identified significant features that suggest a glycolytic disturbance, including a decrease in glyceraldehyde-3-phosphate, a glycolytic intermediate, and 2,3-bisphosphoglycerate, which is produced via conversion of 1,3-bisphosphoglycerate, another metabolite of glycolysis, in the LueberingRapoport glycolytic shunt and is responsible for enhancing oxygen dissociation from hemoglobin (Hb) (4)

These include modulations in gene expression, stimulation of the endocannabinoid system, and action on the central nervous system