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Choose your injection technique based on the amount of subcutaneous tissue present: If you can pinch at least 2.5 cm (1 inch) of skin and fat, gently pinch the thigh between your thumb and fingers to create a raised area If you have adequate subcutaneous tissue, you may inject without pinching Remove the pen cap by pulling it straight off

Clinical pharmacokinetics of oral semaglutide: analyses of data from clinical pharmacology trials

See our dedicated oral tirzepatide guide for that format

Adverse reactions that occurred with a frequency of 1% or less included the following: Cardiovascular:Palpitations, chest pain