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Arg34GLP-1 (9-37) with a modification of Lys at position 26: adding N, N-diisopropylethylamine into 300mL of a mixed solution of acetonitrile and water, cooling to 0-5 , adjusting the pH to 11.5, adding 1g of Arg34GLP-1 (9-37) to form a mixture, dissolving 0.29g of the compound 1 'into 100mL of acetonitrile, dropwise adding the mixture into the mixture, reacting at 0-5 for 1 hour, adjusting the pH of the obtained reaction solution to 5.4 by using acetic acid, then adding 400mL of purified water, and centrifuging to obtain a solid compound 2', wherein the purity is only 75.83%, and a specific liquid chromatogram is shown in FIG

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Elhadef K, Smaoui S, Fourati M, Ben Hlima H, Chakchouk Mtibaa A, Sellem I, et al

This common question reflects an important nutritional challenge faced by patients taking this GLP-1 receptor agonist medication