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"It is therefore recommended that higher thresholds are proposed for fermentation products which can be used for the US market." "In the European market the EMA guideline on setting specifications for related impurities in antibiotics (EMA/CHMP/CVMP/QWP/199250/2009 corr) published 30 June 2012, includes a special threshold for fermentation products," the company added

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For skin specifically, this matters because the accumulation of senescent fibroblasts in aging dermis is one of the primary drivers of collagen loss

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