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The fact that there are several plants used in African traditional medicine, for which little information is available on their constituents, can increase the risk of adverse reactions, particularly in vulnerable groups such as older adults, children, and pregnant women (Mensah et al., 2019

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In contrast, in the Cagri-AMY 1 R-Gs structure, L119 RAMP1 is likely to clash with a rearranged imidazole side chain of H296 ECL2 that is observed when Cagri is bound to CTR and likely accounts for the different orientation of the linker in the Cagri bound AMY 1 R (Fig