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10.1126/scitranslmed.aad7151 59

The Synergy of Combined GHRH and GHRP Using CJC-1295 (a GHRH analog) together with Ipamorelin (a GHRP) produces synergistic rather than merely additive effects

Increases Metabolic Rate Without Muscle Loss AOD-9604 enhances metabolic efficiency by: Upregulating fat-metabolizing enzymes Increasing caloric expenditure at rest Sparing lean muscle massa critical factor in long-term weight management This is in contrast to traditional weight loss approaches, which often result in both fat and muscle loss, leading to a decrease in basal metabolic rate

Interestingly, the residues implicated in product discrimination are two threonines proposed to each interact with the carboxyl group of SA, which in turn is bound in distinct conformations in UGT74F1 and UGT74F2