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A 2021 observational analysis found that adding orlistat to established semaglutide therapy produced minimal additional weight loss (approximately 12 pounds) while increasing adverse events such as gastrointestinal discomfort and fat malabsorption

However, its short half-life in circulation limits its therapeutic utility 5 and, therefore, more stable dualAGs have been developed

Here are some general guidelines to keep in mind: Take once daily, around the same time each day

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