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While both Novo and Lilly's weight-loss drugs carry list prices of more than $1,000, consumers with insurance coverage typically pay far less in copays or other out-of-pocket expenses

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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets