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Fatty acid oxidation in cell peroxisomes also generates succinate, which can also enter this cycle and offers another path for lipids in cell metabolism [94] (Fig

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[46] This theory has been challenged due to the high level of reactivity of the two free sulfhydryls, low intracellular concentrations of DHLA as well as the rapid methylation of one or both sulfhydryls, rapid side-chain oxidation to shorter metabolites and rapid efflux from the cell