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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

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First identified in human plasma, its concentration declines significantly with agefrom approximately 200 ng/mL in youth to 80 ng/mL by the age of 60 (Pickart and Margolina 2018)