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Among the tested compounds, PA and PCA are supposed to be metabolized by ring-hydroxylating and ring-cleavage dioxygenases using molecular oxygen as a co-substrate

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Similarly, absence of EGT led to sensitivity to 40 and 60 M menadione, but not 20 M

The mechanism of action can be summarized in the following three stages: reaction with superoxide anion radical to prevent free radical trigger, inhibition of the Fenton reaction to prevent hydroxyl radical generation, and reaction with lipid peroxidation groups to prevent lipid peroxidation