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24 It must be mentioned that the study had a low patient number of n = 14 and was performed in children with a mean age of 11.8 years when trauma occurred

Anti-inflammatory, anti-apoptotic, and antioxidant effects Further supporting their therapeutic role, PRP and PRF have been shown to reduce the expression of pro-apoptotic and inflammatory markers such as caspase-3, IL-1, and TNF- in animal models of T/D injury [27, 69, 70]

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While the tumors treated with PBS showed an exponential growth, the tumor of the animals treated with Ru(II)-OH, NP2, or NP4 showed a tumor growth inhibition effect