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In 1967, Reese and Karnovsky, through electron microscopy observations, determined that the BBB is primarily composed of astrocyte end feet and capillary endothelial cells[13]

Recombinant human insulin-like growth factor-I (rhIGF-I) therapy in adults with type 1 diabetes mellitus: effects on IGFs, IGF-binding proteins, glucose levels and insulin treatment

Because ERT clinically improves the disease and symptoms but is suboptimal due to the occurrence of irreversible renal injury in cases of late diagnosis 22 , our findings are compatible with the natural clinical course of human Fabry disease

Stem cell patch research more generally Finally, note that the term stem cell patch has several different meanings today