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Buse et al., Management of hyperglycemia in type diabetes, : a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes, Diabetes Care,vol.,no.,pp.,

Previous studies have indicated that the GLP-1 signaling pathway is involved in regulating c-Fos expression and promoting neuronal proliferation [22,33,53], and its enhanced transmission leads to an increase in anxiety-like behaviors [26,46], while the expression of c-Fos in related brain regions is elevated [45,68,69]

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The chronic diabetic state is characterized by hyperglycemia- and lipid-induced inflammatory processes that damage tissues in a potentially self-amplifying manner (1)