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Then, to ulteriorly determine how IGF-1 gene overexpression alleviated SIPS of hepatocytes, primary hepatocytes were transfected the IGF-1 adenovirus vector to overexpress IGF-1 (namely AV-IGF-1) or nontarget adenovirus vector (called AV-CTR), and then treated with H 2 O 2 (200 nM) for 24 h

Moreover, we discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for OA treatment