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However, the diagnostic criteria have not been validated by case-control studies and remain based on expert consensus, mainly from headache neurologists and epidemiological studies from the 1990s

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When Lower Doses May Be Clinically Discussed Some clinicians may consider individualized dose adjustments in situations such as: Significant gastrointestinal intolerance Gradual re-initiation after interruption Unique patient-specific clinical considerations These decisions are individualized and should not be made independently