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Similarly, overexpression of hACOX1 N237S in cultured rat Schwann cells induced apoptosis, and cell death was suppressed by NACA

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However, and interestingly, data also suggested that while GSTP1-1 engages TRAF2 in its dimeric form, only one monomer is involved in binding and therefore the other may still be catalitically competent 30

Additionally, forskolin was shown to further improve the transport and absorption of Bu-PEG NPs by upregulating the expression of MCT-1 on the apical membrane and promoting its recruitment into caveolae, thereby enhancing the in vivo therapeutic effects of BU-NP@Sema [86]