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Features that distinguish acneiform eruptions from acne vulgaris are: a positive time relationship between the introduction of the drug and the onset, a sudden and uncommon age of onset, pruritus, a monomorphic pattern and an involvement of seborrheic and extra-seborrheic areas such as the face, the neck, shoulders, arms, chest, and back [1,8]

Although the overall interactions look similar there are a few differences in the strengths of the interactions

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The effect of copper tripeptide and tretinoin on growth-factor production in a serum-free fibroblast model