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This regulatory effect is largely mediated by microbial metabolites that function as ligands for nuclear receptorsa class of transcription factors that sense xenobiotics and endogenous signaling molecules and coordinate adaptive transcriptional responses ( 7.2.1 Nuclear receptors PXR and FXR as key regulators of drug metabolism Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are key xenobiotic sensors that regulate the expression of phase I enzymes (e.g., CYP3A4, CYP2C), phase II enzymes (e.g., UDP-glucuronosyltransferases), and drug transporters such as P-glycoprotein

16:8 or 5:2), which often creates a calorie deficit naturally without strict calorie counting

But animal studies dont always predict what will happen in people

The dashboard does the rest