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Type 2 diabetes: Excess body fat, especially around the abdomen, contributes to insulin resistance and can lead to type 2 diabetes

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Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4

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