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Indeed, a study published in Diabetes, Obesity and Metabolism found that people regained two-thirds of their original weight a year after stopping the drug semaglutide

As of April 2026, CJC-1295 and Ipamorelin have been removed from the Food and Drug Administrations (FDA) Category 2 restricted list, with formal review of compounding eligibility scheduled for July 2026

Code availability We confirm that EndNote Version 9, a freely available software application, was utilized for reference management, and Biorender, another freely available tool, was employed for the creation of figures in this manuscript

As GLP-1s continue to transform obesity treatment, orthopedic surgeons must balance their benefits with vigilance toward the nutritional and physiologic changes these agents induce prior to elective joint replacement