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The 8mg dose achieved 21.1% weight loss (matching Zepbounds efficacy) with lower side effects: 24% nausea versus 28% at 12mg, 8.4% discontinuation versus 11.2%

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This disease spectrum ranges from isolated lipid deposition within hepatocytes through metabolic dysfunction-associated steatohepatitis (MASH), potentially advancing toward cirrhotic transformation, hepatic functional deterioration, and malignant hepatocellular transformation