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Because it is a long-acting drug, it is typically dosed only once or twice a week rather than daily. Common Side EffectsMost side effects are mild and clear up on their own, but they can include:Nausea and vomiting (taking the tablet with food can help mitigate this)Dizziness or lightheadedness due to a drop in blood pressure (postural hypotension)Headache and fatigueConstipation Yes

No clinical trial has directly compared split dosing to weekly dosing at the same total weekly amount

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Arbutin is a molecule extracted from the bearberry plant that prevents the formation of melanin