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None of the trials included patients that were specifically contraindicated or intolerant of metformin

Switching between GLP-1RA medications should be viewed as a normal part of long-term obesity care, said senior researcher Sarah Messiah, a professor of epidemiology and pediatrics at UT Southwestern Medical Center in Dallas

Working closely with a rheumatologist or primary care provider will ensure that any progress is safely monitored, and it will allow adjustments to the treatment plan as needed

The authors also would like to express their gratitude to the patients who participated in the study, whose cooperation made this work possible