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MOTS-c is often provided as a lyophilized powder that must be reconstituted with bacteriostatic water using sterile technique before use

The women received treatment at one of 68 health care organizations

While not inherently dangerous, too much of it can cause problems, as can too much caffeine derived from other sources

Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration