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Post-mortem studies of the autistic brain samples showed abnormal changes in the steady-state levels of complexes I-IV in the cingulate gyrus, cerebellum, thalamus, and temporal and frontal cortex [79, 80, 86, 122]

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This discrepancy has been attributed to the effect of first-pass metabolism on orally administered estrogen, but the exact mechanism for this, and the impact on total liver fat content, is not clear

Enhancement of heat tolerance by 5-oxp could be associated with the up-regulation or activation of sugar and organic acid metabolism during photosynthesis and respiration, amino acid metabolism for protein synthesis, and the maintenance of nucleotide metabolism for ATP, DNA, and RNA synthesis (Fig8)