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Key considerations for love handle injections include: Adequate subcutaneous tissue depth Absence of excessive scarring or skin changes Proper technique according to the Instructions for Use Individual body composition and comfort with accessing this area Avoiding areas that may be irritated by clothing or belt lines There is no evidence suggesting that injection in the lateral abdominal area produces different efficacy or safety outcomes compared to other approved sites, provided proper subcutaneous technique is maintained

Nevertheless, although off-target inhibition of DPP-9 could be one potential explanation for the association between saxagliptin and heart failure in an experimental setting, it is uncertain whether mean exposure levels of saxagliptin reach a high enough level to affect DPP-9 activity when used at its therapeutic dose in humans