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The specific effects of SCFAs are mediated by several mechanisms, including selective activation of the G-protein-coupled receptors family (GPCR), free fatty-acid receptors (FFARs), or epigenetic effects

Another task to be performed is to identify the functional effector molecules of the driver Latilactobacillus sakei LB-P12 (e.g., SCFAs and bacterial extracellular vesicles) and their pathways for crossing the intestinal epithelial barrier and targeting joint macrophages and chondrocytes

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Similar results have been found in vivo , doses of 4 g/kg body weight of bisphenol-A enhanced the number of BrdU + cells in the rat hippocampus, whereas doses of 40 and 400 g/kg significantly reduce them (Tiwari et al., 2015b)