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3.6.4 Interventions 3.6.4.1 Probiotics Gut dysbiosis has been increasingly recognized as a contributor to cardiovascular disease (CVD) pathogenesis through mechanisms involving systemic inflammation and metabolic disruption, with probiotics and prebiotics emerging as promising strategies to restore microbiota balance and improve cardiovascular markers such as LDL cholesterol and high-sensitivity C-reactive protein (hs-CRP

The two compounds work via distinct but complementary pathways: CJC-1295 (No DAC): Functions as a GHRH mimetic

Klotz K, Goen T

Specific details on the rodent transgenic mutation reporter assays are reviewed in Lambert et al