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A multicenter, randomized, double-blind, placebo-controlled clinical trial involving 300 participants with melasma evaluated the effect of a product containing 30% salicylic acid and 10% niacinamide over 16 weeks

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The results demonstrated a highly concentrated distribution of the time to the inflection point (i.e., the onset of the logarithmic growth phase) within each group, confirming the excellent detection reproducibility of the system