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Research shows that this exposure triggers inflammation through elevated expression of cytokines such as IL-1, IL-1, IL-6, IL-8, TNF, and MCP-1, and upregulates inflammatory markers like RAGE and COX-2, disrupting the immune balance within the mouth (Table 9)

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Langan et al5 reported the first cases of transformation of preexisting nevi in 2 women (aged 30 and 48 years, phototype I/II) after they had used Melanotan I and II