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Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss

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It may also contribute to improved fat utilization, muscle recovery, and heart health

CFTR-dependent regulation of adult-type enterocyte genes was observed following treatment with TGF1 and FGF2, similar to the effects of EV39, with the exception of amino acid transporter genes (Fig